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KMID : 1142020230580000066
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Blood Research
2023 Volume.58 No. 0 p.66 ~ p.82
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Mycosis fungoides and Sezary syndrome
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Lee Hye-Won
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Abstract
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Mycosis fungoides (MF) and Sezary syndrome (SS) are a distinct disease entity of cutaneous T-cell lymphoma with heterogenous clinical features and prognosis. MF mainly involves skin and usually shows an indolent and favorable clinical course. In patients with advanced-stage disease, extracutaneous involvement including lymph nodes, viscera, and blood, or large cell transformation may be observed. SS is a leukemic form of advanced- stage MF, characterized by generalized erythroderma. Early-stage MF can be treated with skin-directed therapy. However, patients with refractory or advanced-stage disease are associated with severe symptoms or poor prognosis, requiring systemic therapy. Recent progress in understanding the pathogenesis of MF/SS has contributed to advances in the management of these rare diseases. This review aims to describe the clinical manifestations, diagnosis, risk stratification, and treatment strategy of MF/SS, focusing on the recent updates in the management of these diseases.
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KEYWORD
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Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma, Diagnosis, Prognosis, Treatment
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